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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue <t>Homogenate.</t> One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.
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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue <t>Homogenate.</t> One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.
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left kidney  (Bertin Technologies)
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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue <t>Homogenate.</t> One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.
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kidney tissue homogenates  (Elabscience Biotechnology)
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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue <t>Homogenate.</t> One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.
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kidney protein homogenates  (Bio-Rad)
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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue <t>Homogenate.</t> One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.
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kidney homogenate supernatant  (Tecan Systems)
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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue <t>Homogenate.</t> One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.
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Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue Homogenate. One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.

Journal: Journal of Inflammation Research

Article Title: Effects of Zofenopril and Thymoquinone in Cyclophosphamide-Induced Urotoxicity and Nephrotoxicity in Rats; The Value of Their Anti-Inflammatory and Antioxidant Properties

doi: 10.2147/JIR.S500375

Figure Lengend Snippet: Effect of ZOF and TQ alone and their combination on Kidney Injury Biomarkers. ( A ) KIM-1 and ( B ) Cys-C in Kidney Tissue Homogenate. One-way ANOVA multiple comparison was used followed by Tukey’s test. Number of animals per each group=8. *p=0.0175 PC vs MS, **p=0.007 PC vs ZOF, *p=0.04 PC vs TQ, **p=0.0055 PC vs ZOF+TQ in 5A; *p=0.019 PC vs NC, *p=0.031 PC vs ZOF+TQ, **p=0.007 PC vs MS and TQ, in 5B are statistically significant.

Article Snippet: The concentration of cystatin C (Cys-C) ng/mL and kidney injury molecule-1 (KIM-1) ng/mL in the supernatant of kidney tissue homogenate were determined using Rat CYS-C (Cat.No.E0145Ra) and KIM-1 (Cat.No.E0549Ra) BT LAB ELISA Kit from Bioassay technology laboratory, Shanghai, China strictly following the manufacturer’s instructions.

Techniques: Comparison